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                            Home > Products > Intermediates > Other Intermediates > Raltegravir intermediate CAS 518048-03-8

                            Raltegravir intermediate CAS 518048-03-8

                            Basic Info

                            Function: Antibiotic and Antimicrobial Agents

                            Grade Standard: Medicine Grade

                            Type: Chemical Reagent

                            State: Solid

                            Volatile: Not Volatile

                            Product Description


                            Intermediates of Raltegravir, offered by us can be seen from the list shown below. Please click on the intermediate name to browse through more details of the intermediate required by you. If you can not locate your required intermediate for Raltegravir on this page, you may send us a sourcing request for the specific Raltegravir intermediate you are looking for along with its Cas No, and the Intermediate name and we shall come back to you promptly with more details.
                            Raltegravir is an antiviral medicine that prevents human immunodeficiency virus(HIV) from multiplying in your body. Raltegravir is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Raltegravir is not a cure for HIVor AIDS.
                            Integration of the HIV-1 viral DNA generated by reverse transcription of the RNA genome into the host cell chromosomes is a key step of viral replication, catalyzed by the viral integrase. In October 2007, the first integrase inhibitor, raltegravir, was approved for clinical use under the name of Isentress. The results of the various clinical trials that have evaluated raltegravir have been very encouraging with regard to the immunological and virological efficacy and tolerance. However, as observed for other anti-retrovirals, specific resistance mutations have been identified in patients failing to respond to treatment with raltegravir. Although knowledge of the integrase structural biology remains fragmentary, the structures and modeling data available might provide relevant clues on the origin of the emergence of these resistance mutations. In this review, we describe the mechanism of action of this drug and the main data relating to its use in vivo, together with recent structural data important to our understanding of the origin of viral resistance.

                            Chemical Name: 2-(1-AMINO-1-METHYLETHYL)-N-(4-FLUOROBENZYL)-5-HYDROXY-1-METHYL-6-OXO-1,6-DIHYDROPYRIMIDINE-4-CARBOXAMIDE
                            Molecular Formula: C16H19FN4O3
                            Formula Weight: 334.35
                            CAS No.: 518048-03-8


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