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                            Home > Products > Intermediates > Other Intermediates > Epalrestat intermediate cas 5718-83-2

                            Epalrestat intermediate cas 5718-83-2

                            Product Description

                            Chemical Name: Rhodanine-3-acetic acid
                            Molecular Formula: C5H5NO3S2
                            Formula Weight: 191.23
                            CAS No.: 5718-83-2

                            5718-83-2



                            Chemical Name: Epalrestat

                            Molecular Formula: C15H13NO3S2

                            Formula Weight: 319.4

                            CAS No.: 82159-09-9

                            82159-09-9

                            Chemical Name: alpha-Methylcinnamaldehyde

                            Molecular Formula: C10H10O

                            Formula Weight: 146.19

                            CAS No.: 101-39-3

                            101-39-3
                            Epalrestat is a carboxylic acid derivative and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus. It reduces the accumulation of intracellular sorbitol which is believed to be the cause of diabetic neuropathy, retinopathy and nephropathy. It is well tolerated, with the most commonly reported adverse effects being gastrointestinal issues such as nausea and vomiting, as well as increases in certain liver enzymes. Chemically, epalrestat is unusual in that it is a drug that contains a rhodanine group. Aldose reductase is the key enzyme in the polyol pathway whose enhanced activity is the basis of diabetic neuropathy. Aldose reductase inhibitors (ARI) target this enzyme. Out of the many ARIs developed, ranirestat and fidarestat are in the trial stage. Others have been discarded due to unacceptable adverse effects or weak efficacy. Epalrestat is the only ARI commercially available. It is easily absorbed into the neural tissue and inhibits the enzyme with minimum side effects.


                            Looking for ideal Eabeth Impurity Cas 82159-09-9 Manufacturer & supplier ? We have a wide selection at great prices to help you get creative. All the Epatat Intermediate Cas 101-39-3 are quality guaranteed. We are China Origin Factory of Carboxymethyl Rhodanine Antidiabetic. If you have any question, please feel free to contact us.

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