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                            Home > Products > Intermediates > Apixaban Intermediates > Apixaban intermeidate Cas 545445-44-1

                            Apixaban intermeidate Cas 545445-44-1

                            Product Description

                            Chemical Name: 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

                            Molecular Formula: C20H25N3O3
                            Formula Weight: 355
                            CAS No.: 545445-44-1

                            545445-44-1
                            An alternate approach to Apixaban was described. The synthesis features a novel and cost-effective synthetic strategy to construct a key N-phenylvalerolactam intermediate 4 from 4-nitroaniline. In addition, the modifiedStroke Prophylaxis with Atrial Fibrillation
                            Indicated to reduce risk of stroke and systemic embolism associated with nonvalvular atrial fibrillation

                            5 mg PO BID

                            Postoperative Prophylaxis of DVT/PE
                            Indicated following hip or knee replacement surgery

                            Initial: Give 2.5 mg PO 12-24 hr after surgery

                            Duration of therapy (hip replacement): 2.5 mg PO BID for 35 days

                            Duration of therapy (knee replacement): 2.5 mg PO BID for 12 days

                            Renal impairment, including with ESRD on dialysis

                            Deep Vein Thrombosis: No dose adjustment recommended; clinical efficacy and safety studies did not enroll patients with ESRD on dialysis or patients with a CrCl <15 mL/min; dosing recommendations are based on pharmacokinetic and pharmacodynamic (anti-FXa activity) data in study subjects with ESRD maintained on dialysis
                            synthetic route avoids the use of expensive reagents and significantly improves reaction yields. As demonstrated practically, apixaban was successfully synthesized in overall good yield (35%).


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