Diquafosol is a dinucleoside derivative of uridine that acts as a selective P2Y2 receptor agonist. The product belongs to Antifungal class. Diquafosol is used as a therapeutic agent in the treatment of dry eye syndrome.
A pyrimidine ribonucleoside 5'-tetraphosphate compound having 5'-uridinyl residues at the P1- and P4-positions.
Diquafosol (tradename Diquas) is a pharmaceutical drug for the treatment of dry eye disease. It was approved for use in Japan in 2010. It is formulated as a 3% ophthalmic solution of the tetrasodium salt.
Diquafosol is a drug used for dry eye treatment with a novel mechanism of action. It stimulates the secretion of tear fluid and mucin on the ocular surface, thus enabling us to selectively treat the tear film layer, playing an important role in the establishment of the concept of [Tear Film Oriented Therapy (TFOT)", an effective therapeutic approach to dry eye in Japan. The 3% diquafosol ophthalmic solution has been widely used for the treatment of dry eye in clinical practice, and it is currently available in Japan and South Korea. This review provides an overview of the clinical utility of 3% diquafosol ophthalmic solution, focusing on the results of clinical studies on various types of dry eye, including aqueous-deficient dry eye, short tear film breakup time-type dry eye, and post dry eye after laser in situ keratomileusis. It also introduces the additive effect of diquafosol on sodium hyaluronate monotherapy for dry eye, and the effect of 3% diquafosol ophthalmic solution for dry eye-related conditions. Additionally, it summarizes the ocular effects of diquafosol in healthy human eyes. Lastly, the importance of improving tear film stability in dry eye treatment, as well as general advances in dry eye treatments, are described.
Its mechanism of action involves agonism of the P2Y2 purinogenic receptor.
Key words of the product are Diquafosol Sodium Salt Tetrahydrogen Tetraphosphate,Diquafosol Purity 99% White Powder and Diquas Dry Eye Disease Medicine
Molecular Formula: C18H26N4O23P4
CAS No.: 59985-21-6
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Product Categories : Antifungal/Antibiotic/Antimicrobial