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                            Home > Products > Anesthetic/Anesthesia > Bupivacaine api Bupivacaine base intermediate cas 2180-92-9

                            Bupivacaine api Bupivacaine base intermediate cas 2180-92-9

                            Basic Info

                            Function: Anesthetic and Adjuvant

                            Grade Standard: Medicine Grade

                            Type: Chemical Reagent

                            State: Solid

                            Volatile: Not Volatile

                            Product Description

                            Product: Bupivacaine

                            CAS NO.: 2180-92-9

                            Standard: BP,CP,USP

                            Molecular Formula: C18H28N2O

                            Molecular Weight: 288.43

                            Description: White crystal or crystalline powder

                            Package: 25KG/drums

                            Chemical names, synonyms:

                            MARCAINE, BUPIVACAINE, BUPIVACAINE BASE, Anekain, Carbostesin, DL-Bupivacaine, LAC-43, WIN 11318, win11318

                            Minimum purity: 99%

                            Bupivacaine 2180-92-9


                            Bupivacaine is a widely used local anesthetic agent.
                            from MeSH
                            Bupivacaine is an amide-type, long-acting local anesthetic. Bupivicaine reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.
                            Pharmacology from NCIt
                            Bupivacaine is only found in individuals that have used or taken this drug. It is a widely used local anesthetic agent. [PubChem]Bupivacaine blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Bupivacaine binds to the intracellular portion of sodium channels and blocks sodium influx into nerve cells, which prevents depolarization. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: (1) pain, (2) temperature, (3) touch, (4) proprioception, and (5) skeletal muscle tone. The analgesic effects of Bupivicaine are thought to potentially be due to its binding to the prostaglandin E2 receptors, subtype EP1 (PGE2EP1), which inhibits the production of prostaglandins, thereby reducing fever, inflammation, and hyperalgesia.


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                            Product Categories : Anesthetic/Anesthesia

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